February 15th, 2001 will be remembered as a pivotal day in medical history as The Human Genome Project (HGP) consortium published its results of 90% of the three billion base pairs of the human genome in the journal Nature. Since then there has been great excitement in targeted therapies of illness. Although the true genetic nature of glaucoma has been somewhat elusive, there have been strides in certain genetic makers for specific types of glaucoma. This lecture is divided into 3 sections: the first reviews the basics of genetics and the current discoveries in genetic loci of glaucoma. The second will focus on using genetic data to customize our medical management of the disease. The last will explore the genetic factors that may determine success of surgical management and finally, a brief discussion on future of glaucoma management including neuro-protection and ganglion cell regeneration. With in-office and home-based genetic testing kits becoming increasingly common.
- 1. Go over the basic science of genomics and inherited disease
- 2. Discuss protein expression and environmental factors
- 3. Literature review of the current genes associated with glaucoma
- 4. Explore the possibility of choosing the best surgical treatment based on genetic info
- 5. Review advances in neuro-protection and possible neuro-regeneration